Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC020
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-03 11:05
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Requip modutumab a 20mg 1x1 tbl Jumex a 5mg 1x1 Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 39 individuals with a value less than 0.71 were subsequently diagnosed with PD. That is, 92.86% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.71 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 15, 'TN': 12, 'TP': 27, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 4, 'TP': 39, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 4, 'TP': 37, 'FP': 26}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.992
timePerCircleCoV 0.258535
timePerCircleSlope -0.0705654
meanError 2.25134
tremorFreq 6.83594
tremorRelPower 19.8572
tremorGyroAmpMean 0.0101632
tremorGyroAmpSlope -0.0130013
tremorGyroAmpCoV 0.411085
tremorCoordAmpMean 0.0385997
tremorCoordAmpSlope 0.008794
tremorCoordAmpCoV 0.273481
tremorAccAmpMean 0.0192474
tremorAccAmpSlope -0.00196252
tremorAccAmpCoV 0.324964
tremorPcRelVar 0.691215
tremorPcX 0.707907
tremorPcY -0.706305

Circle Segment 1

Duration 4.32 s, Accuracy Estimate 2.22 (lower is better)

Circle Segment 2

Duration 6.32 s, Accuracy Estimate 1.832 (lower is better)

Circle Segment 3

Duration 4.84 s, Accuracy Estimate 1.725 (lower is better)

Circle Segment 4

Duration 4.4 s, Accuracy Estimate 2.061 (lower is better)

Circle Segment 5

Duration 3.92 s, Accuracy Estimate 2.285 (lower is better)

Circle Segment 6

Duration 3.6 s, Accuracy Estimate 2.223 (lower is better)

Circle Segment 7

Duration 3.28 s, Accuracy Estimate 2.361 (lower is better)

Circle Segment 8

Duration 3.16 s, Accuracy Estimate 2.36 (lower is better)

Circle Segment 9

Duration 3.0 s, Accuracy Estimate 2.606 (lower is better)

Circle Segment 10

Duration 3.08 s, Accuracy Estimate 2.84 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 10.076
timePerSpiralCoV 0.100594
timePerSpiralSlope -0.0274039
meanError 2.32573
tremorFreq 6.83594
tremorRelPower 19.2501
tremorGyroAmpMean 0.0169393
tremorGyroAmpSlope -0.000647153
tremorGyroAmpCoV 0.365249
tremorCoordAmpMean 0.0478789
tremorCoordAmpSlope 0.00513344
tremorCoordAmpCoV 0.247833
tremorAccAmpMean 0.0255883
tremorAccAmpSlope 0.000580975
tremorAccAmpCoV 0.382751
tremorPcRelVar 0.637982
tremorPcX -0.661352
tremorPcY 0.750076

Spiral Segment 1

Duration 12.44 s, Accuracy Estimate 2.021 (lower is better)

Spiral Segment 2

Duration 11.0 s, Accuracy Estimate 2.307 (lower is better)

Spiral Segment 3

Duration 9.92 s, Accuracy Estimate 2.384 (lower is better)

Spiral Segment 4

Duration 9.84 s, Accuracy Estimate 2.354 (lower is better)

Spiral Segment 5

Duration 10.08 s, Accuracy Estimate 2.214 (lower is better)

Spiral Segment 6

Duration 10.12 s, Accuracy Estimate 2.506 (lower is better)

Spiral Segment 7

Duration 9.84 s, Accuracy Estimate 2.136 (lower is better)

Spiral Segment 8

Duration 9.28 s, Accuracy Estimate 2.321 (lower is better)

Spiral Segment 9

Duration 8.8 s, Accuracy Estimate 2.774 (lower is better)

Spiral Segment 10

Duration 9.44 s, Accuracy Estimate 2.238 (lower is better)

Elel

eDurationMean 0.2594
eDurationStd 0.033551
eDurationStdnorm 0.129341
eDurationMedian 0.25
eDurationQuartdelta 0.0325
eDurationQuartdeltanorm 0.13
eDurationKurt 7.68119
eDurationTrenddiff -0.035
eDurationTrendratio 0.872727
eWidthMean 6.4584
eWidthStd 1.19413
eWidthStdnorm 0.184895
eWidthMedian 6.318
eWidthQuartdelta 1.66725
eWidthQuartdeltanorm 0.263889
eWidthKurt 3.25183
eWidthTrenddiff -1.2285
eWidthTrendratio 0.825
eHeightMean 14.1476
eHeightStd 1.46247
eHeightStdnorm 0.103372
eHeightMedian 14.157
eHeightQuartdelta 2.25225
eHeightQuartdeltanorm 0.159091
eHeightKurt 3.10422
eHeightTrenddiff -1.8135
eHeightTrendratio 0.878906
eAspectMean 0.456248
eAspectStd 0.0683355
eAspectStdnorm 0.149777
eAspectMedian 0.435897
eAspectQuartdelta 0.0962813
eAspectQuartdeltanorm 0.220881
eAspectKurt 2.3449
eAspectTrenddiff -0.0435656
eAspectTrendratio 0.907743
eSlantMean -0.079216
eSlantStd 0.134117
eSlantStdnorm -1.69306
eSlantMedian -0.101695
eSlantQuartdelta 0.198014
eSlantQuartdeltanorm -1.94714
eSlantKurt 2.64803
eSlantTrenddiff -0.0781258
eRtopMean 0.700348
eRtopStd 0.075393
eRtopStdnorm 0.107651
eRtopMedian 0.705882
eRtopQuartdelta 0.10215
eRtopQuartdeltanorm 0.144712
eRtopKurt 2.60278
eRtopTrenddiff -0.0241572
eRbotMean 0.899775
eRbotStd 0.281321
eRbotStdnorm 0.312657
eRbotMedian 0.888889
eRbotQuartdelta 0.380976
eRbotQuartdeltanorm 0.428598
eRbotKurt 2.56112
eRbotTrenddiff 0.17794
eRrightMean 0.863659
eRrightStd 0.0332641
eRrightStdnorm 0.0385154
eRrightMedian 0.862385
eRrightQuartdelta 0.0459761
eRrightQuartdeltanorm 0.0533127
eRrightKurt 2.296
eRrightTrenddiff -0.025044
eRleftMean 0.461643
eRleftStd 0.0867259
eRleftStdnorm 0.187864
eRleftMedian 0.467742
eRleftQuartdelta 0.114112
eRleftQuartdeltanorm 0.243963
eRleftKurt 2.41116
eRleftTrenddiff 0.0446406
lDurationMean 0.292045
lDurationStd 0.0213619
lDurationStdnorm 0.0731458
lDurationMedian 0.2875
lDurationQuartdelta 0.035
lDurationQuartdeltanorm 0.121739
lDurationKurt 2.32494
lDurationTrenddiff -0.03
lDurationTrendratio 0.903226
lWidthMean 5.47241
lWidthStd 1.55131
lWidthStdnorm 0.283479
lWidthMedian 5.3235
lWidthQuartdelta 2.106
lWidthQuartdeltanorm 0.395604
lWidthKurt 2.94535
lWidthTrenddiff -1.521
lWidthTrendratio 0.74
lHeightMean 25.1178
lHeightStd 2.29539
lHeightStdnorm 0.0913851
lHeightMedian 25.3305
lHeightQuartdelta 3.861
lHeightQuartdeltanorm 0.152425
lHeightKurt 1.7483
lHeightTrenddiff -3.861
lHeightTrendratio 0.857759
lAspectMean 0.215935
lAspectStd 0.0479442
lAspectStdnorm 0.222031
lAspectMedian 0.20833
lAspectQuartdelta 0.0600032
lAspectQuartdeltanorm 0.28802
lAspectKurt 2.7843
lAspectTrenddiff -0.0264905
lAspectTrendratio 0.884717
lSlantMean -0.126105
lSlantStd 0.088783
lSlantStdnorm -0.704041
lSlantMedian -0.139982
lSlantQuartdelta 0.103998
lSlantQuartdeltanorm -0.742941
lSlantKurt 2.86535
lSlantTrenddiff -0.09912
lRtopMean 0.719642
lRtopStd 0.116251
lRtopStdnorm 0.161541
lRtopMedian 0.725067
lRtopQuartdelta 0.152679
lRtopQuartdeltanorm 0.210572
lRtopKurt 2.59743
lRtopTrenddiff -0.0571809
lRbotMean 1.39435
lRbotStd 0.414406
lRbotStdnorm 0.297203
lRbotMedian 1.32229
lRbotQuartdelta 0.699038
lRbotQuartdeltanorm 0.528656
lRbotKurt 1.70127
lRbotTrenddiff 0.543011
lRrightMean 0.874121
lRrightStd 0.0517886
lRrightStdnorm 0.0592464
lRrightMedian 0.877949
lRrightQuartdelta 0.0814649
lRrightQuartdeltanorm 0.09279
lRrightKurt 2.4462
lRrightTrenddiff -0.0234537
lRleftMean 0.479478
lRleftStd 0.113406
lRleftStdnorm 0.23652
lRleftMedian 0.486402
lRleftQuartdelta 0.191646
lRleftQuartdeltanorm 0.394008
lRleftKurt 2.17227
lRleftTrenddiff 0.0711857

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

FITTS Short Modified

meanTouchScore 0.966667
sumTouchScores 29
meanMovementTime 0.635517
numTouches 30
undershootPercentage 0
overshootPercentage 3.33333

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.947061
sumTouchScores 17.9942
meanMovementTime 1.00639
numTouches 19
undershootPercentage 5.26316
overshootPercentage 0

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 15.12
timePerZigzagCoV 0.0566471
timePerZigzagSlope 0.00873016
meanError 2.4008
tremorFreq 5.95703
tremorRelPower 26.5554
tremorGyroAmpMean 0.0198083
tremorGyroAmpSlope -0.0052494
tremorGyroAmpCoV 0.291476
tremorCoordAmpMean 0.0506158
tremorCoordAmpSlope -0.00442624
tremorCoordAmpCoV 0.272505
tremorAccAmpMean 0.038309
tremorAccAmpSlope -0.00276377
tremorAccAmpCoV 0.325647
tremorPcRelVar 0.736374
tremorPcX 0.0517061
tremorPcY 0.998662

ZigZag Segment 1

Duration 14.04 s, Accuracy Estimate 2.638 (lower is better)

ZigZag Segment 2

Duration 15.28 s, Accuracy Estimate 2.402 (lower is better)

ZigZag Segment 3

Duration 16.4 s, Accuracy Estimate 2.191 (lower is better)

ZigZag Segment 4

Duration 15.08 s, Accuracy Estimate 2.415 (lower is better)

ZigZag Segment 5

Duration 14.8 s, Accuracy Estimate 2.358 (lower is better)

ZigZag Offset

numZigzags 7
timePerZigzagMean 10.0171
timePerZigzagCoV 0.25899
timePerZigzagSlope 0.0730177
zigzagHeightMean 54.1521
zigzagHeightCoV 0.0892807
zigzagHeightSlope 0.0321538
meanError 0.0455043
tremorFreq 6.15234
tremorRelPower 26.1214
tremorGyroAmpMean 0.0238504
tremorGyroAmpSlope -0.00648873
tremorGyroAmpCoV 0.363391
tremorCoordAmpMean 0.0479835
tremorCoordAmpSlope -0.00422011
tremorCoordAmpCoV 0.305367
tremorAccAmpMean 0.0750763
tremorAccAmpSlope -0.000290475
tremorAccAmpCoV 0.106552
tremorPcRelVar 0.797793
tremorPcX -0.424208
tremorPcY 0.905565

ZigZag Offset Segment 1

Duration 10.0 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 2

Duration 9.08 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 6.92 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 6.92 s, Accuracy Estimate 0.051 (lower is better)

ZigZag Offset Segment 5

Duration 11.16 s, Accuracy Estimate 0.074 (lower is better)

ZigZag Offset Segment 6

Duration 13.72 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 7

Duration 12.32 s, Accuracy Estimate 0.045 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.71}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.1264406836119325}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.22845413910155932}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6967248766672534}